Volume 10 Issue 1

Solanum melongena Fruits and Leaf Extracts can Inhibit Advanced Glycation End Products (AGEs) and 1-diphenyl-2-Picryl-hydrazyl (DPPH) Radical In vitro: A Preliminary Study

Hauwa

Abstract

Background: Oxidative stress is a deleterious effect of several diseases and is linked to production of advanced glycation end products (AGEs). Nigeria and other countries use medicinal herbs, such Solanum melongena L. (Solanaceae), extensively for the traditional treatment of illnesses. Aim: The current study aimed at assessing phytochemical components, in vitro antioxidant and antiglycation properties of extracts from S. melongena fruit and leaves. Methods: AGEs derived from incubating bovine serum albumin (BSA) and glucose was characterized by Spectro-fluorescence. Fruit and leaf samples were extracted with chloroform, ethyl acetate and methanol and tested for antioxidant and antiglycation activities following phytochemical constituents evaluation. Results: Our result indicated the presence of alkaloids, saponins and flavonoids in all the plant extracts. Furthermore, the chloroform extract of the fruit displayed a significant (p < 0.05) activity on 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging (97.21%) and antiglycation assay (79.14%), compared to other extracts. Additionally, the ethyl acetate extract of the leaves exhibited significantly more potent DPPH radical scavenging (86%) and antiglycation (79%) activities compared to other extracts, respectively. Conclusion: Evidence from this study demonstrated that fruit and leaves of S. melongena, particularly the chloroform and ethyl acetate extract, has potent antioxidant and antiglycation potentials that necessitate further research studies to identify the active key principles.

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