Volume 9 Issue 2

Sweet orange (Citrus sinensis) juice mitigates some pathophysiological disorders in D-galactose-induced aging in rats

Habeeb

Abstract

Aging is associated with several pathophysiological alterations that cause a decline in the functions and physiological activities of an
organism. Citrus sinensis (Sweet orange) is the most consumed citrus fruit for nutritional and pharmacological purposes. This study
investigated the anti-aging effects of C. sinensis juice in D-galactose-induced aging rats. Five female Wistar rats each were randomly
assigned to four different groups, namely: control (distilled water), aging (D-galactose), orange juice (D-galactose and sweet orange),
and the standard (D-galactose and quercetin). Antioxidant enzymes in the heart, liver, kidney, and brain were monitored, while lipid
profile was estimated in the blood. Serum inflammatory markers and female sex hormones were also monitored using the ELISA kits.
Administration of D-galactose increased the level of LDL-Cholesterol in the model group, however, administration of C. sinensis
significantly reduced it in the treated group. Superoxide dismutase (SOD) and catalase (CAT) activities were significantly increased in
the tissues of the treated animals (p < 0.05). The juice has no significant effect on estradiol and luteinizing hormone. C. sinensis juice
could mitigate some pathophysiological alterations associated with aging processes by improving tissue antioxidant capacity, reducing
inflammation, as well as dyslipidemia.

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